Configuration settings to change environment

Are there any specific recommendations for configuration settings to run yugabyte in a multi-region environment compared to a multi-zone (AZ) environment in AWS or GCP?

I do expect the latency of operations to be higher in a multi-region deployment. But in terms of system configuration, are there any best practice settings for such deployments in order to handle transient network blips better?

One configuration that will help is putting all leaders (if possible) in 1 region. This will lower latency of transactions: https://docs.yugabyte.com/latest/admin/yb-admin/#set-preferred-zones

cc @neha for more